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French reporter who joined police exposes racism and violence
Valentin Gendrot spent almost six months as a police officer in a tough northern district of Paris. Photograph: Joel Saget/AFP/Getty Images

Valentin Gendrot spent almost six months as a police officer in a tough northern district of Paris. Photograph: Joel Saget/AFP/Getty Images

Covid vaccine rush could make pandemic worse, say scientists
Experts say strong evidence of efficacy needed to avoid approval of inferior vaccines
A scientist at work at a Covid-19 vaccine laboratory in Oxford. Photograph: Reuters
The rush to immunise populations against Covid-19 could lead to the rollout of a vaccine that is not very effective and risk worsening the pandemic, leading scientists have said.
Politicians and commercial companies are competing to be the first to license a vaccine, but experts say the world would be better served by waiting until comprehensive results showed at least 30-50% effectiveness.
Ministers announced on Friday that the UK would take emergency powers to push any vaccine through the regulatory processes with unprecedented speed before the end of the year. Donald Trump wants to be able to announce the US has a vaccine before tthe presidential election on 3 November.
A vaccine is vital to stopping the pandemic, but Prof Sir Richard Peto of Oxford University and an adviser to the World Health Organization, said the first vaccine would be bought and used all over the world even if it had low efficacy.
Even if it protected only a minority of the population, it would be regarded as the standard by which later vaccines would be measured. That could even lead to inferior vaccines being approved, because they would not have to show that they were any better.
“I think there’s a big rush, a somewhat nationalistic rush and also somewhat capitalistic rush as well, to be absolutely first to register a vaccine, and it will actually make it more difficult to evaluate other vaccines,” Peto said.
“We do need a vaccine that works and we need it soon,” but “we really do need quite strong evidence of efficacy”.
There is huge political and commercial momentum in the UK behind the Oxford/AstraZeneca vaccine, which is ahead of most other contenders in the world. Trials are taking place in a number of countries, including those with high levels of infection, such as South Africa and Brazil, where how well it works will become clear more quickly .
The Department of Health said on Friday that it planned to take emergency measures to ensure the UK could licence a vaccine this year if it had sufficient evidence of safety and efficacy. Until 31 December, the UK would otherwise have to wait for the European Medicines Agency to approve a vaccine. Next year, post-Brexit, the UK will license its own vaccines and drugs.
In its consultation document on changing the law, the government says the UK’s joint committee on vaccines and immunisation (JCVI) will be responsible for recommending that a vaccine that should go forward for licensing. That committee is chaired by Prof Andrew Pollard, the director of the Oxford Vaccine Group, who has said they may have enough data to give to regulators before the end of the year.
Peto is a member of the WHO’s Solidarity Vaccines Trial Expert Group, which is made up of leading scientists around the world who are advising on the establishment of the WHO’s trial to compare different vaccine candidates.
The group said in the Lancet medical journal last week that a poor vaccine would be worse than no vaccine, not least because people who had it would assume they were no longer at risk and stop social distancing.
“Deployment of a weakly effective vaccine could actually worsen the Covid-19 pandemic if authorities wrongly assume it causes a substantial reduction in risk, or if vaccinated individuals wrongly believe they are immune, hence reducing implementation of, or compliance with, other Covid-19 control measures,” they said.
They urged all regulators to stick to the WHO’s guidance, which says that no vaccine that is less than 30% effective should be approved. It recommends at least 50% effectiveness, but allowing for 95% accuracy that could mean 30% in practice.
The Food and Drug Administration, the US regulator, has said it will abide by the 30% guidance, but some observers think it may come under political pressure to license a vaccine that falls below that threshold.
The Lancet piece says trials such as Solidarity, which compare various vaccines, are a better way to proceed.
“In comparison with individual trials for each of the many different vaccines, a global multi-vaccine trial with a shared control group could provide more rapid and reliable results,” they write.
“High enrolment rates facilitated by flexible trial design and hundreds of study sites in high-incidence locations could yield results on short-term efficacy for each vaccine within just a few months of including that vaccine.”
Good results on safety and effectiveness do not guarantee there will be no long-term problems, they add. The vaccine’s protection may wane, for instance.
“The trial costs will be a fraction of the societal costs of Covid-19, and this global collaboration could rebut detrimental vaccine nihilism and vaccine nationalism,” they write.

The former MI6 officer Christopher Steele had a “personal” relationship with Ivanka Trump and gifted her a “family tartan from Scotland” as a present, the long-awaited report by US Department of Justice inspector general, Michael Horowitz, revealed on Monday.
Horowitz’s review of the FBI’s 2016 investigation into Donald Trump’s 2016 election campaign and its links with Russia includes fresh details of Steele’s interactions with the FBI, and startling claims about his relationship with the Trumps dating back to the period before he wrote a controversial dossier on Trump.
The report did not mention Ivanka Trump by name but her identity was revealed by ABC News.
The report said that contrary to what Donald Trump has claimed on Twitter Steele was actually “favorably disposed” to the Trump family. It was “ridiculous” to suggest he was biased against the then Republican candidate or that his memos on collusion, written at the behest of the Washington-based research firm Fusion GPS, were in any way biased, Steele told federal investigators.
Steele said he had visited Ivanka Trump at Trump Tower and had been “friendly” with her for “some years”. He described their relationship as “personal”. The former British government spy had even given her a “family tartan from Scotland” as a present, the report quoted him as saying.
ABC also reported that Ivanka Trump even discussed work that Steele’s firm – Orbis Business Intelligence – might do for the Trump family business.
Earlier this year Steele met with members of the inspector general’s team in London and spoke to investigators via Skype. He handed over memos setting out his two meetings in 2016 with the FBI, in which he passed on his dossier which said that the Russians had been seeking to cultivate Trump for some years, and had secretly compromised him in a Moscow hotel room.
Horowitz’s conclusions were sent to Orbis ahead of the report’s publication on Monday. This prompted Steele to issue an unusual statement via his lawyers pushing back against some of the inspector general’s key claims.
The report concludes the FBI placed too much emphasis on Steele’s work. It said Steele’s reporting was not done “in bad faith” but sometimes showed a “lack of judgement” and could involve pursuing people with “political risk but no intelligence value”.
On Monday Steele’s Washington-based law firm, Bredhoff & Kaiser, issued a lengthy rebuttal of Horowitz’s findings and defended Steele’s professional work.
It said that the Trump-Russia memos written by Steele in 2016 were derived from “credible and reliable” human sources. Subsequently his reporting was “extensively corroborated”, the lawyers said.
Some of this confirmation came from testimony given by Carter Page, Trump’s former foreign policy aide.
Page is at the centre of the Horowitz review. The president appointed Horowitz after Republicans claimed Page was the victim of “illegal” FBI spying in 2016, with a surveillance warrant issued by a federal court in part because of the dossier. The report finds that the FBI made multiple mistakes and errors in its handling of the Page case.
Page admitted that in 2016 he met with senior officials from the Kremlin and the oil firm Rosneft in Moscow. This was what the dossier reported, Steele’s lawyers pointed out. They added that Steele’s memos – published by BuzzFeed – were never “meant to be made public”. The report further quotes Steele as saying his field work was meant to be “briefed off of orally” rather than consumed as a “written product”.
Donald Trump has repeatedly blasted Steele on Twitter, describing him as a “failed spy” and his dossier as “phoney”.
The dossier says Russia’s president, Vladimir Putin, launched a multi-faceted campaign to boost Trump ahead of the 2016 election. Robert Mueller confirmed “sweeping and systematic” Russian interference but did not establish that Trump had engaged in a criminal-level conspiracy.